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Abstract Objective: To describe the prevalence of underweight and obesity indicators among individuals registered as traditional peoples and communities in the Food and Nutrition Surveillance System, across Brazil, in 2019. Methods: This was a descriptive study using individual secondary data from participants receiving care in the Primary Health Care within the Brazilian National Health System. Results: In the study population (N = 13,944), there was a higher prevalence of short stature among male children and adolescents (14.2%), when compared to their female counterparts (11.8%); in the adult female population, there was a higher prevalence of obesity (23.0%), when compared to the male population (11.3%); the prevalence of low height-for-age in riverine communities (18.5%) and obesity in the adult faxinalense population (75.1%) stood out. Conclusion: Anthropometric disparities between different communities require tailored responses, emphasizing targeted primary health care and programs to ensure food and nutrition security.
Resumen Objetivo: Describir la prevalencia de indicadores de bajo peso y obesidad entre individuos registrados como pueblos y comunidades tradicionales en el Sistema de Vigilancia Alimentaria y Nutricional, en todo Brasil, en 2019. Métodos: Estudio descriptivo, con datos secundarios individuales de participantes atendidos en atención primaria de Salud del Sistema Único de Salud. Resultados: En la población estudiada (N = 13.944), hubo mayor prevalencia de talla baja en niños y adolescentes en el sexo masculino (14,2%), cuando se compara con el femenino (11,8%); en la población adulta femenina hubo mayor prevalencia de obesidad (23,0%), en comparación con la masculina (11,3%); se destacó la prevalencia de baja talla para la edad en comunidades ribereñas (18,5%), y obesidad en la población adulta faxinalense (75,1%). Conclusiones: Las heterogeneidades antropométricas entre comunidades requieren respuestas adaptadas, con énfasis en la atención primaria de salud y en garantizar la seguridad alimentaria y nutricional.
Resumo Objetivo: Descrever a prevalência de indicadores de baixo peso e de obesidade entre os indivíduos registrados como povos e comunidades tradicionais no Sistema de Vigilância Alimentar e Nutricional, de todo o Brasil, em 2019. Métodos: Estudo descritivo, com dados individualizados secundários de participantes atendidos na Atenção Básica do Sistema Único de Saúde. Resultados: Na população estudada (N = 13.944), houve maior prevalência de altura baixa entre crianças e adolescentes do sexo masculino (14,2%), quando comparados aos do sexo feminino (11,8%); na população adulta do sexo feminino, observou-se maior prevalência de obesidade (23,0%), quando comparada à do sexo masculino (11,3%); destacou-se a prevalência de altura baixa para a idade nas comunidades ribeirinhas (18,5%), e de obesidade na população adulta faxinalense (75,1%). Conclusões: As heterogeneidades antropométricas entre as comunidades exigem respostas adaptadas, com ênfase na atenção primária à saúde e na garantia da segurança alimentar e nutricional.
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El cáncer de ovario es un problema de salud pública para el cual no se cuenta con métodos de tamizaje estandarizados, no obstante, los marcadores Ca125, He4 y el índice de Roma tiene un gran valor en el diagnóstico y pronóstico de esta patología. Objetivo. Analizar el comportamiento de los marcadores tumorales Ca125 y He4 e índice de Roma en la predicción de malignidad en pacientes con masas ováricas. Materiales y Métodos. Se tomaron los resultados de laboratorio de 112 mujeres atendidas en el Hospital General Ambato de los valores séricos de Ca125, He4 y su correspondiente cálculo del índice de Roma. Se los dividió en el grupo pre y postmenopáusico, maligno y benigno. Resultados. El análisis de los resultados definió la relación de Ca 125 y He4 con el diagnóstico de cáncer de ovario con un nivel de confianza del 95% y valor de p<0,05. La probabilidad de diferenciar cáncer de ovario de procesos benigno para Ca125, He4 e índice de Roma fue del 93,33%, 84,4 y 99,7, respectivamente. Conclusiones. El mejor predictor de malignidad es el índice de Roma. Se encontraron valores séricos elevados de He4 mayores para pacientes postmenopáusicas. Se requieren más estudios que avalen un método de tamizaje estandarizado para el cáncer de ovario.
Ovarian cancer is a public health problem for which there are no standardized screening methods; however, Ca125, He4 and Rome index markers are of great value in the diagnosis and prognosis of this pathology. Objective. To analyze the behavior of tumor markers Ca125 and He4 and Rome index in the prediction of malignancy in patients with ovarian masses. Materials and Methods. The laboratory results of 112 women attended at Hospital General Ambato were taken for serum Ca125, He4 and their corresponding calculation of the Rome index. They were divided into premenopausal and postmenopausal, malignant and benign groups. Results. Analysis of the results defined the relationship of Ca 125 and He4 with the diagnosis of ovarian cancer with a confidence level of 95% and value of p<0.05. The probability of differentiating ovarian cancer from benign processes for Ca125, He4 and Rome index was 93.33%, 84.4 and 99.7, respectively. Conclusions. The best predictor of malignancy is the Rome index. Elevated serum He4 values were found to be higher for postmenopausal patients. Further studies are needed to support a standardized screening method for ovarian cancer.
O câncer do ovário é um problema de saúde pública para o qual não existem métodos de triagem padronizados. No entanto, os marcadores índice Ca125, He4 e Roma são de grande valor no diagnóstico e prognóstico desta patologia. Objetivo. Analisar o comportamento dos marcadores tumorais Ca125 e He4 e o índice de Roma na previsão de malignidade em pacientes com massas ovarianas. Materiais e métodos. Os resultados laboratoriais de 112 mulheres tratadas no Hospital Geral Ambato foram tomados para o soro Ca125, He4 e seu correspondente cálculo do índice de Roma. Eles foram divididos em grupos pré e pós-menopausa, malignos e benignos. Resultados. A análise dos resultados definiu a associação de Ca125 e He4 com o diagnóstico de câncer de ovário a um nível de confiança de 95% e valor de p<0,05. A probabilidade de diferenciar o câncer de ovário dos processos benignos para Ca125, He4 e índice de Roma foi de 93,33%, 84,4 e 99,7, respectivamente. Conclusões. O melhor preditor de malignidade é o índice de Roma. Os valores elevados de soro He4 foram considerados mais altos para pacientes na pós-menopausa. São necessários mais estudos para apoiar um método padronizado de triagem para o câncer de ovário.
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Ovarian Neoplasms , Public HealthABSTRACT
SUMMARY Objective: This review aim to report the results of the most recent research and applications of different extracts of P. granatum in the in vivo wound healing process. Methods: For the survey of articles in literature, a search was conducted in the PubMed, Scopus, Science Direct and Science Citation Index Expanded (Web of Science) databases. Results: Punica granatum is a plant native to Iran and adjacent regions widely used worldwide as a food and medicinal source. Its healing property is closely linked to the presence of phenolic compounds, tannins and flavonoids, and its concentration in treatment formulations seems to be determinant for the acceleration of tissue repair, although few data on the standardization and stability of these formulations are available. Studies on experimental models were able to demonstrate the repair potential of P. granatum; however, human studies are still scarce. Conclusions: This contribution summarizes the use of P. granatum extracts in healing different types of lesions, emphasizing its effects on inflammatory, prolif-erative, and remodeling phases.
Objetivo: Relatar los resultados de investigaciones y aplicaciones más recientes de diferentes extractos de P. granatum en el proceso de cicatrización de heridas in vivo. Métodos: Para encuesta de artículos en la literatura, se realizó búsqueda en las bases de datos PubMed, Scopus, Science Direct y Science Citation Index Expanded (Web of Science). Resultados: Punica granatum es una planta originaria de Irán y regiones adyacentes, ampliamente utilizada en todo el mundo como fuente alimenticia y medicinal. Su propiedad cicatrizante está íntimamente ligada a la presencia de compuestos fenólicos, taninos y flavonoides, y su concentración en las formulaciones de tratamiento parece ser determinante para aceleración de la reparación tisular, aunque se dispone de pocos datos sobre estandarización y estabilidad de estas formulaciones. Estudios sobre modelos experimentales pudieron demostrar el potencial de reparación de P. granatum; sin embargo, los estudios en humanos aún son escasos. Conclusiones: Este aporte resume el uso de extractos de P. granatum en la curación de diferentes tipos de lesiones, enfatizándose sus efectos en las fases inflamatoria, proliferativa y remodeladora.
Objetivo: Relatar os resultados de pesquisas mais recentes e aplicações de diferentes extratos de P. granatum no processo de cicatrização in vivo. Métodos: Para levantamento de artigos na literatura, realizou-se busca nas bases de dados PubMed, Scopus, Science Direct e Science Citation Index Expanded (Web of Science). Resultados: Punica granatum é uma planta nativa do Irã e das regiões adjacentes, amplamente utilizada em todo o mundo como alimento e fonte medicinal. A propriedade cicatrizante está intimamente ligada à presença de compostos fenólicos, taninos e flavo-noides, cuja concentração nas formulações de tratamento parece ser determinante para aceleração do reparo tecidual, embora poucos dados sobre a padronização e estabilidade dessas formulações estejam disponíveis. Estudos em modelos experimentais foram capazes de demonstrar o potencial de reparo de P. granatum. No entanto, estudos em humanos ainda são escassos. Conclusões: Esta contribuição resume o uso de extratos de P. granatum na cicatrização de diferentes tipos de lesões, enfatizando os efeitos nas fases inflamatória, proliferativa e remodelação.
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Acinetobacter baumannii is a multi-drug resistant microorganism. The objective of this study was to evaluate the antimicrobial and antibiofilm action of the pomegranate natural extract against eight strains of multidrug resistant Acinetobacter baumanii and to assess the extract cytotoxicity in a culture of Human Keratinocytes (HaCat). Broth microdilution method was used to determine the minimum inhibitory and minimum microbicidal concentrations of the extracts. The extract antibiofilm action was analysed by the MTT colorimetric test. The cytotoxicity evaluation was performed by the MTT colorimetric test, which analysed the mitochondrial cellular action, after contact of the extract for 5 min. The results were statistically analysed by ANOVA and Tukey test with a significance level α≤ 0.05. Punica granatum L. (pomegranate) extract had antimicrobial action on all the 8 clinical strains of Acinetobacter baumannii evaluated. The extract showed a significant reduction in metabolic action in biofilm for all the strains, with results statistically different from growth control (p≤0.05%). P. granatum extract applied for 5 min on human keratinocytes (HaCat) promoted cell viability in all the tested concentrations. The pomegranate extract is effective in reducing the multidrug-resistant clinical strains of Acinetobacter baumanni and is biocompatible. (AU)
Acinetobacter baumannii é um microrganismo multirresistente. O objetivo deste estudo foi avaliar a ação antimicrobiana e antibiofilme do extrato natural de romã contra oito cepas de A. baumanii multirresistente e avaliar a citotoxicidade do extrato em uma cultura de queratinócitos humanos (HaCat). O método de microdiluição em caldo foi utilizado para determinar as concentrações inibitórias mínimas e microbicidas mínimas dos extratos. A ação antibiofilme do extrato foi analisada pelo teste colorimétrico MTT. A avaliação da citotoxicidade foi realizada pelo teste colorimétrico MTT, que analisou a ação celular mitocondrial, após contato do extrato por 5 min. Os resultados foram analisados ââestatisticamente por ANOVA e teste de Tukey com nível de significância α≤ 0,05. O extrato de Punica granatum L. (romã) apresentou ação antimicrobiana em todas as 8 cepas clínicas avaliadas de A. baumannii. O extrato apresentou redução significativa na ação metabólica no biofilme para todas as linhagens, com resultados estatisticamente diferentes do controle de crescimento (p≤0,05%). O extrato de P. granatum aplicado por 5 min em queratinócitos humanos (HaCat) promoveu viabilidade celular em todas as concentrações testadas. O extrato de romã é eficaz na redução das cepas clínicas multirresistentes de Acinetobacter baumanni e é biocompatível. (AU)
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RESUMEN Introducción: Los desórdenes gastrointestinales funcionales pediátricos, comprenden un conjunto de síntomas gastrointestinales crónicos o recurrentes, no explicados por anomalías estructurales o bioquímicas, con interferencia importante en la calidad de vida del niño y su familia. Objetivo: Determinar la prevalencia de los desórdenes gastrointestinales funcionales en adolescentes. Métodos: Estudio observacional, descriptivo de corte transversal, prospectivo con 318 adolescentes pertenecientes a los centros de enseñanza del reparto Camilo Cienfuegos del municipio Habana del Este, en el período comprendido entre marzo 2020 y enero del 2021. Las variables utilizadas fueron edad, sexo, antecedentes personales de dengue, antecedentes familiares de desórdenes gastrointestinales familiares, primogénito, padres separados, hijo único, prematuridad y nacimiento por cesárea. Se utilizó el cuestionario para síntomas digestivos pediátricos, basado en los criterios de Roma IV. Resultados: Un total de 93 estudiantes, para 29,2 % cumplieron los criterios diagnósticos de Roma IV para algún desorden gastrointestinal funcional. Se encontró predominio del sexo femenino (34,3 %) y del grupo de 10-12 años (30 %). El estreñimiento funcional se diagnosticó en 22,7 % de los adolescentes, seguido de la dispepsia funcional en 3,5 %. Conclusiones: Los desórdenes gastrointestinales funcionales son comunes en los adolescentes del estudio. El estreñimiento funcional es el trastorno más frecuente. Los desórdenes gastrointestinales funcionales se presentan de forma significativa en adolescentes del sexo femenino.
ABSTRACT Introduction: Pediatric functional gastrointestinal disorders comprise a set of chronic or recurrent gastrointestinal symptoms, not explained by structural or biochemical abnormalities, with significant interference in the quality of life of the child and his/her family. Objective: Determine the prevalence of functional gastrointestinal disorders in adolescents. Methods: Observational, descriptive cross-sectional, prospective study with 318 adolescents belonging to the educational centers of Camilo Cienfuegos neighborhood, Habana del Este municipality, in the period between March 2020 and January 2021. The variables used were age, sex, personal history of dengue, family history of gastrointestinal disorders, firstborn, separated parents, only child, prematurity and birth by cesarean section. The questionnaire for pediatric digestive symptoms, based on the Rome IV criteria, was used. Results: A total of 93 students (29.2%) met the diagnostic criteria of Rome IV for some functional gastrointestinal disorder. A predominance of the female sex (34.3%) and the group of 10-12 years (30%) was found. Functional constipation was diagnosed in 22.7% of adolescents, followed by functional dyspepsia (3.5%). Conclusions: Functional gastrointestinal disorders are common in the studied adolescents. Functional constipation is the most common disorder. Functional gastrointestinal disorders occur significantly in female adolescents.
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ABSTRACT Objective: To determine the prevalence of functional gastrointestinal disorders (FGIDs) in children according to Rome IV criteria. Methods: We included cohorts and observational descriptive studies, including information for the prevalence of FGIDs according to Rome IV criteria in children 4 to 18 years old. We searched the MEDLINE (Ovid), EMBASE, LILACS, and CENTRAL databases from May 2016 to nowadays. Gray literature and other databases were also consulted. The risk of bias was assessed using the STROBE Statement. The results were reported in forest plots of the estimated effects of the included studies with a 95% confidence interval (95%CI). Results: We included 14 studies involving a total of 17427 participants. Three studies were conducted in Europe, two in North America, and nine in Latin America. Most studies were school-based (n=14670, 84.18%), participants were mostly female (55.49%), white (51.73%), 8 to 18 years old (77.64%), and assisted to a public school (81.53%). Thirteen studies used the Questionnaire on Pediatric Gastrointestinal Symptoms (QPGS-RIV) to assess FGIDs. We found a global prevalence for FGIDs of 23% (95%CI 21-25%, I2 99%). Main disorders were functional constipation (FC) with 12% (95%CI 11-15%) followed by functional dyspepsia (FD) (5%, 95%CI 11-15%) and irritable bowel syndrome (IBS) (3%, 95%CI 2-4%). The prevalence of FGIDs was higher in the Americas, representing 23.67% (95%CI 21.2-26.2%, I2 91.3%). Conclusion: FGIDs are present in one of four children and adolescents, representing a common condition in this age group the central disorders were FC, FD, and IBS.
RESUMO Objetivo: Determinar a prevalência de distúrbios gastrointestinais funcionáis (DGF) em crianças de acordo com os critérios de Roma IV. Métodos: Incluímos coortes e estudos observacionais descritivos, incluindo informações para a prevalência de DGF de acordo com os critérios de Roma IV em crianças de 4 a 18 anos. Pesquisamos nas bases de dados MEDLINE (Ovid), EMBASE, LILACS e CENTRAL de maio de 2016 até os dias atuais. A literatura cinzenta e outras bases de dados também foram consultadas. O risco de viés foi avaliado usando a Declaração STROBE. Os resultados foram relatados em parcelas florestais dos efeitos estimados dos estudos incluídos com um intervalo de confiança de 95% (95%IC). Resultados: Foram incluídos 14 estudos envolvendo um total de 17.427 participantes. Três estudos foram realizados na Europa, dois na América do Norte e nove na América Latina. A maioria dos estudos foi de base escolar (n=14.670, 84,18%), os participantes eram em sua maioria do sexo feminino (55,49%), brancos (51,73%), de 8 a 18 anos (77,64%) e atendidos em escola pública (81,53%). Treze estudos usaram o Questionário de Sintomas Gastrointestinais Pediátricos (QPGS-RIV) para avaliar DGF. Encontramos uma prevalência global de DGF de 23% (95%IC 21-25%, I2 99%). Os principais distúrbios foram constipação funcional (CF) com 12% (95%IC 11-15%) seguido de dispepsia funcional (DF) (5%, 95%IC 11-15%) e síndrome do intestino irritável (SII) (3%, 95%IC 2-4%). A prevalência de DGF foi maior nas Américas, representando 23,67% (95%IC 21, 2-26,2%, I2 91,3%). Conclusão: DGF estão presentes em uma de quatro crianças e adolescentes, representando uma condição comum nessa faixa etária. Os distúrbios centrais foram CF, DF e SII.
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ABSTRACT Background Chronic abdominal pain (CAP) carries a significant burden of disease. The last edition of the Rome Criteria (Rome IV) allows the diagnosis of functional gastrointestinal disorders (FGIDs) according to symptoms-based criteria; however, patients continue to experience a delay in their diagnosis and to be submitted to different interventions before the establishment of a positive diagnosis. Objective We aimed to characterize etiology, clinical features, and interventions in a pediatric cohort of patients with CAP secondary to FGIDs, who were referred to our tertiary care university-affiliated hospital, in Brazil. Methods A retrospective descriptive study of children and adolescents (aged 20 years and younger) referred to our institution, from January/2013 to December/2018, for CAP, and who fulfilled criteria for FGIDs classified according to Rome IV criteria. Results Three hundred twenty-eight patients with CAP were screened, of which 67.9% (223 patients) fulfilled the criteria for FGIDs and were included in the study. Sixty percent were female, with a mean age of 8.3 years. At the time of referral, the mean duration of symptoms was 2.8 years. Length/height for age and weight for age mean z-scores were -0.08±1.87 and -0.38±1.62, respectively. Functional abdominal pain not otherwise specified was overall the most common diagnosis (70.4%). Before establishing the diagnosis of FGIDs, multiple pharmacological interventions were described, while after, the mainstay of therapy was education/reassurance and dietary interventions. Thirty-two percent of patients did not further require specialized follow-up. Conclusion Even at the tertiary care level, FGIDs were still the most common etiology of chronic abdominal pain, particularly functional abdominal pain not otherwise specified. Despite the relatively long duration of symptoms at referral, cessation of specialized care follow-up was possible in approximately a third of the cases.
RESUMO Contexto A dor abdominal crônica (DAC) pode acarretar importante morbidade. A última edição dos Critérios de Roma (Roma IV) permite o diagnóstico de distúrbios gastrointestinais funcionais (DGIFs) de acordo com critérios baseados em sintomas; no entanto, esses pacientes continuam a apresentar atraso no diagnóstico e a serem submetidos a diferentes intervenções antes do estabelecimento de um diagnóstico. Objetivo Caracterizar a etiologia, características clínicas e intervenções de crianças com DAC que não são mantidas na atenção primária e que foram encaminhadas ao nosso hospital universitário de nível terciário, no Brasil. Métodos Estudo retrospectivo descritivo de crianças e adolescentes (com idade igual ou inferior a 20 anos) encaminhados a nossa instituição, entre janeiro/2013 e dezembro/2018, por DAC e que preenchiam os critérios para DGIFs conforme o consenso de Roma IV. Resultados Trezentos e vinte e oito pacientes com DAC foram triados, 67,9% (223 pacientes) preencheram os critérios para DGIFs e foram analisados. Sessenta por cento do sexo feminino, com idade média de 8,3 anos. A duração média dos sintomas no encaminhamento era de 2,8 anos. Os escores z médios de estatura para idade e peso para idade foram -0,08±1,87 e -0,38±1,62, respectivamente. Dor abdominal funcional sem outra especificação foi o diagnóstico mais comum (70,4%). Antes do diagnóstico de DGIFs, múltiplas intervenções farmacológicas foram descritas, enquanto depois, a base da terapia foi a educação, passar segurança à família e intervenções dietéticas. Trinta e dois por cento dos pacientes apresentaram resolução dos sintomas e receberam alta do acompanhamento especializado. Conclusão Mesmo no nível terciário, as desordens gastrointestinais funcionais ainda constituem a etiologia mais comum da DAC, particularmente a dor abdominal funcional não especificada. Apesar da duração longa dos sintomas, alta do serviço especializados foi possível em aproximadamente um terço dos casos.
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Infantile colic(IC)is a common process that occurs in the infants within five months of age.The main characteristic of IC is paroxysm of inconsolable crying.Although IC is a benign self-limiting process, it is a common source of concern for family, and usually bring challenge to doctors.The diagnostic criteria is Roma Ⅳ criteria, which is mainly based on the typical feature and duration of crying.The etiology is unknown.The proposed causes can be classified into gastrointestinal and non-gastrointestinal factors.There is still no standard treatment for IC.The current management includes dietary modification, behavioral modification, pharmacological intervention, manual therapy, and so on.More clinical studies are needed to confirm the effect of these treatment strategies.Pediatricians should be familiar with the main causes and management of IC, and should also be adept at recognizing the individual reasons, managing the infants, and improving the prognosis.
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ABSTRACT: The effect of sunflower oil (SO), sunflower oil-pomegranate sauce (PS1) and sunflower oil-plum sauce (PS2) on shelf life of marinated carp fillets was investigated in terms of sensory evaluation, chemical (peroxide value (POV), thiobarbituric acid (TBA), free fatty acids (FFA), total volatile basic nitrogen (TVB-N) and pH), and microbiological properties (Total viable count (TVC), Escherichia coli, Total coliform, Staphylococci/Micrococci, Salmonella spp.) during 30 days of storage. Proximate composition, which includes total crude protein%, fat%, moisture% and ash% of fresh carp fillets before marination process was analyzed and found 18.69±0.86, 4.08±0.19, 74.33±0.63 and 2.17±0.45, respectively. Sensory evaluation analysis showed that total appearance, odor-taste and texture scores decreased during storage. TVB-N significantly increased in all group after 1 month of storage (P<0.05). At the end of storage, the lowest TBA value (1.38 mg MA/kg carp fillet) was determined in the PS1 group. During storage, the highest POV value was observed in the control group (8.49 mEq O2/kg) compared to other groups. Initial TVC of 1.5 log CFU/g, 1.7 log CFU/g and 1.8 log CFU/g increased to 3.7 log CFU/g, 2.9 log CFU/g and 3.2 log CFU/g in SO, PS1 and PS2 groups, respectively. Results showed that the shelf life of marinated carp fillets treated with sunflower oil and in combination with pomegranate and plum sauce was more than 1 month.
RESUMO: O efeito do óleo de girassol (SO), molho de óleo de girassol-romã (PS1) e molho de óleo de girassol-ameixa (PS2) na vida útil de filetes de carpa marinados foi investigado em termos sensorial, químico (valor de peróxido (PV), ácido tiobarbitúrico) (TBA), ácidos graxos livres (AGL), nitrogênio básico volátil total (TVB-N) e pH) e propriedades microbiológicas (contagem viável total (TVC), Escherichia coli, coliforme total, estafilococos/Micrococos, Salmonella spp.). Durante 30 dias de armazenamento. A composição aproximada, que inclui % de proteína bruta total, % de gordura, % de umidade e % de cinzas de filés de carpa frescos antes do processo de marinação foi analisada e encontrada 18,69 ± 0,86, 4,08 ± 0,19, 74,33 ± 0,63 e 2,17 ± 0,45, respectivamente. A análise sensorial mostrou que os escores totais de aparência, odor e sabor diminuíram durante o armazenamento. TVB-N aumentou significativamente (P <0,05) em todos os grupos após 1 mês de armazenamento. No final do armazenamento, o menor valor de TBA (1,38 mg MA / kg de filé de carpa) foi determinado no grupo PS1. Durante o armazenamento, o maior valor de POV foi observado no grupo controle (8,49 mEq O2/kg) em comparação com outros grupos. O TVC inicial de 1,5 log CFU/g, 1,7 log UFC/g, 1,8 log CFU/g aumentou para 3,7 log CFU/g, 2,9 log CFU/g, 3,2 log CFU/g nos grupos SO, PS1 e PS2, respectivamente. Os resultados mostraram que a vida útil dos filés de carpa marinados tratados com óleo de girassol e em combinação com molho de romã e ameixa era superior a um mês.
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Objective@#To compare the clinical significance of human epididymis protein 4(HE4), CA125, ROMA in the differential diagnosis of ovarian cancer.@*Methods@#From May 2016 to October 2017, 240 patients with ovarian tumor in Xuzhou Cancer Hospital were selected.According to the result of postoperative pathology, the patients were divided into benign ovarian disease group(n=120) and ovarian cancer group(n=120). And 100 healthy women from medical examination center were selected as control group.The electrochemiluminescence (ECLIA) technique was used to assess the serum levels of CA125, HE4, and ROMA was calculated.The clinical significance of HE4, CA125, ROMA in the differential diagnosis of ovarian cancer was analyzed by statistic methods.@*Results@#The CA125, HE4 concentrations and ROMA in the ovarian cancer group[(370.9±213.2)U/mL, (364.4±227.0)pmpl/L, (80.2±26.1)%]were higher than those in the benign ovarian disease group and the health control group(all P<0.01), there were no statistically significant differences between the benign ovarian disease group and the healthy control group(P=0.356, P=0.321, P=0.292). The sensitivity, specificity, positive and negative predictive values, accuracy of ROMA were higher than those of HE4 and CA125.By using the ROC analysis, the AUC for CA125, HE4, ROMA were 0.832, 0.888, 0.960, respectively, AUC(CA125)<AUC(HE4)<AUC(ROMA).@*Conclusion@#CA125 and HE4 have important value in the diagnosis of ovarian cancer, but the ROMA shows the best diagnostic performance and actual value.
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Objective To compare the clinical significance of human epididymis protein 4(HE4),CA125, ROMA in the differential diagnosis of ovarian cancer.Methods From May 2016 to October 2017,240 patients with ovarian tumor in Xuzhou Cancer Hospital were selected .According to the result of postoperative pathology ,the patients were divided into benign ovarian disease group ( n =120 ) and ovarian cancer group ( n =120 ) .And 100 healthy women from medical examination center were selected as control group .The electrochemiluminescence ( ECLIA ) technique was used to assess the serum levels of CA 125,HE4,and ROMA was calculated .The clinical significance of HE4,CA125,ROMA in the differential diagnosis of ovarian cancer was analyzed by statistic methods .Results The CA125,HE4 concentrations and ROMA in the ovarian cancer group [(370.9 ±213.2) U/mL,(364.4 ±227.0) pmpl/L, (80.2 ±26.1)％] were higher than those in the benign ovarian disease group and the health control group ( all P<0.01),there were no statistically significant differences between the benign ovarian disease group and the healthy control group(P=0.356,P=0.321,P=0.292).The sensitivity,specificity,positive and negative predictive values , accuracy of ROMA were higher than those of HE 4 and CA125.By using the ROC analysis ,the AUC for CA125,HE4, ROMA were 0.832,0.888,0.960,respectively,AUC(CA125) <AUC(HE4) <AUC(ROMA).Conclusion CA125 and HE4 have important value in the diagnosis of ovarian cancer ,but the ROMA shows the best diagnostic performance and actual value .
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Abstract Background Irritable bowel syndrome (IBS) is a common gastrointestinal disorder; celiac disease is an autoimmune enteropathy that can mimic any functional gastrointestinal disorder. The aim of this study is to estimate the prevalence of celiac disease antibodies (anti Tissue Transglutaminase-tTG) in patients with irritable bowel syndrome. Patients and methods This cross sectional study was conducted on 70 patients with irritable bowel syndrome fulfilling Rome III criteria who visited Azadi Teaching Hospital in Duhok city-Iraq. Patients were classified according to irritable bowel syndrome subtypes into: Diarrhoea Predominant (D-IBS), Constipation Predominant (C-IBS) and Mixed (M-IBS). IgA and IgG anti tTG were used to screen patients for celiac disease. Results A total number of 70 patients (44 females and 26 males) were included; their mean age was 33 years (SD ± 7.64). Five patients (7.1%) were found to have positive both IgA and IgG anti tTG. Three of them have had D-IBS and the other two had C-IBS. No one of the M-IBS patients tested positive. Conclusion The prevalence of anti tTG antibodies in irritable bowel syndrome is high. Patients with D-IBS should be screened for celiac disease.
Resumo Introdução A síndrome do intestino irritável (SII) é um distúrbio gastrointestinal comum; a doença celíaca é uma enteropatia autoimune que pode imitar qualquer distúrbio gastrointestinal funcional. O objetivo deste estudo foi estimar a prevalência de anticorpos contra a doença celíaca (antitransglutaminase tecidual - tTG) em pacientes com SII. Pacientes e Métodos Este estudo transversal foi conduzido em 70 pacientes com síndrome do intestino irritável que atendiam aos critérios de Roma III e se apresentaram ao Hospital de Ensino Azadi na cidade de Duhok, no Iraque. Os pacientes foram classificados de acordo com os subtipos de síndrome do intestino irritável em: predominantemente diarreia (D-SII), predominantemente constipação (C-SII) e mista (M-SII). IgA e IgG antitTG foram usados para rastrear pacientes com doença celíaca. Resultados Um total de 70 pacientes (44 mulheres e 26 homens) foram incluídos; a idade média foi de 33 anos (DP ± 7,64). Cinco pacientes (7,1%) apresentaram IgA e IgG antitTG positivos. Três deles tinham D-SII e os outros dois tinham C-SII. Nenhum dos pacientes com M-SII apresentou teste positivo. Conclusão A prevalência de anticorpos antitTG na SII é alta. A presença de doença celíaca deve ser avaliada em pacientes com D-SII.
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Humans , Male , Female , Celiac Disease , Celiac Disease/immunology , Irritable Bowel Syndrome , Antibodies/immunology , Immunoglobulin A , Immunoglobulin G , IraqABSTRACT
Resumen Introducción: Los reportes extranjeros dan cuenta de la presencia de esta patología en cifras que varían entre 10 y 70%, con sólo un reporte nacional centrado en ancianos institucionalizados. Existen diferentes formas de evaluar la presencia de constipación; en nuestra experiencia utilizamos los nuevos criterios de ROMA IV que define como constipación funcional cuando se cumplen dos o más criterios. Objetivos: Determinar la prevalencia y el perfil epidemiológico de pacientes adultos sanos con constipación. Material y Método: Estudio de corte transversal realizado entre enero y marzo de 2018. Se incluyen mayores de 18 años que acceden a completar la encuesta. Se excluye aquellas personas con antecedentes quirúrgicos o mórbidos gastrointestinales. Se realiza encuesta aplicando los criterios de ROMA IV considerando aspectos demográficos. Se utiliza estadística descriptiva. Resultados: De 1.500 encuestas realizadas se seleccionan 1.223. Un 68,4% cumplían con dos o más criterios de constipación funcional, con diferencias estadísticamente significativas en el grupo de sexo femenino y en pacientes de mayor edad. El análisis específico de cada criterio de ROMA IV muestra que los síntomas más frecuentes fueron deposiciones duras, esfuerzo defecatorio excesivo y sensación de evacuación incompleta. Hubo diferencias estadísticamente significativas en mujeres en los ítems: menor frecuencia, deposiciones duras y esfuerzo defecatorio mientras que la mayor edad se asocia a evacuación incompleta. Las maniobras digitales fueron poco frecuentes. Conclusiones: La constipación es frecuente en la población adulta sana afectando, principalmente, a mujeres de mayor edad. Los síntomas más frecuentes fueron deposiciones duras, esfuerzo defecatorio y sensación de evacuación incompleta.
Introduction: The prevalence of this condition has been reported in foreign studies in around 10-70%, with only one national report focused in the institutionalized elderly. There are different diagnostic approaches to determine the presence of functional constipation, in our experience, we use the ROME IV diagnostic criteria, which requires the presence of two or more criteria for confirmation. Aim: To determine the prevalence and epidemiologic profile of healthy adults with constipation disorder. Materials and Method: Transversal cohort study between January-March 2018. Inclusion criteria are 18 years and above. We exclude patients with gastrointestinal medical or surgical comorbidities. Data are collected from a face-to-face survey based on the ROME IV criteria, considering demographic features. Descriptive statistics are used to analyze the results. Results: From a total of 1,500 questionnaire surveys, 1,223 are selected. Two or more criteria for functional constipation were present in 68.4%, with significant statistical differences in the female and elderly population. When analyzing each criterion separately, hard stools, straining and sensation of incomplete evacuation were the most common responses. In women, less frequency, hard stools and straining items showed significant statistical differences, whereas sensation of incomplete evacuation was the highlight in the elderly. Manual maneuvers to facilitate defecation was the less selected item. Conclusions: Functional constipation is a frequent condition seen in healthy adults. Older female population are particularly prone to it. Hard stools, straining, and incomplete evacuation sensation were the most common symptoms.
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Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Constipation/complications , Constipation/epidemiology , Prevalence , Surveys and QuestionnairesABSTRACT
Este artigo propõe-se a apresentar pesquisa bibliográfica em história da ciência soviética (ou sistema soviético de produção científica) e seus desdobramentos na psicologia entre 1948 e 1953. Realizou-se uma revisão de literatura em português em bases de dados, livros e periódicos de ciências humanas, além de livros e artigos relevantes em português e inglês sobre o panorama sócio-histórico em que o sistema científico soviético se constituiu. Quanto ao período compreendido entre 1950 e 1953, os resultados descrevem de que modo a desastrosa "michurinização " das ciências, ou seja, a adoção da agrobiologia de Michurin tal como proposta pelo pseudocientista Trofim Lissenko à guisa de paradigma de pesquisa nas ciências agrárias, repercutiu na psicologia como "pavlovização", ou seja, a orientação de que todas as produções científicas seguissem na direção de Pavlov. Os resultados descrevem o "efeito-cascata" das chamadas "sessões pavlovianas", abordando seus impactos na psicologia, em particular, sobre A.R. Luria e A.N. Leontiev.
This paper aims to present a bibliographic research in history of Soviet Science (or soviet system of science production) and its developments in psychology from 1948 to 1953. For this, we have gathered data by means of a review of references in Portuguese in the SciELO database, books and journals of the human sciences, and readings of significant books and articles in English language on the social and historic background of the constitution of soviet system of science production. The results describe how the affair Lyssenko and his Michurinist viewpoint led the scientists to follow a Pavlovian framework between 1950 and 1953 as the mandatory Party line for many Sciences, including psychology. We analyze how the affair Lyssenko led to a cascade of sessions in different scientific academies, which affected some leading researchers in psychology in that time, from which we singled out Luria and Leontiev.
Este artículo se propone presentar la literatura en la historia de la ciencia soviética (o sistema soviético de la producción científica) y sus desarrollos en la psicologia, entre 1948 y 1953. Hemos hecho una revisión de literatura en português en bases de datos, libros y revistas de humanidades, así como libros y artículos relevantes en Inglês y português en el contexto socio-histórico en el que se formó el sistema científico. En cuanto al período comprendido entre 1950 y 1953, los resultados describen de quê modo la "michurinización" de las ciencias, en el seno del caso Lissenko, repercutió en lapsicología como "pavlovización", o sea, la orientación de que todas lasproducciones científicas siguieran en la dirección de Pavlov. Los resultados describen el "efecto-cascada" de las llamadas "sesiones pavlovianas", abordando los impactos en la psicología, en particular, sobre A.R. Luria y A.N. Leontiev.
Cet article propose de présenter une recherche bibliographique sur lhistoire de la science soviétique (ou système de production scientifique soviétique) et ses développements en psychologie entre 1948 et 1953. Une revue de la littérature a été réalisée en portugais dans des portails scientifiques, livres et périodiques en plus que des livres et des articles pertinents en portugais et en anglais sur le panorama socio-historique dans lequel le système scientifique soviétique a été constitué. Pour ce qui est de la période entre 1950 et1953, les résultats décrivent comment la "michurinisation" désastreuse des sciences, c'est-à-dire l'adoption de l'agrobiologie de Michurin proposée par le pseudo-scientifique Trofim Lissenko comme paradigme de la recherche en sciences de l'agriculture, a eu des répercussions. en psychologie comme "pavlovisation", c 'est-à-dire l 'orientation de toute la production scientifique à suivre Pavlov. Les résultats décrivent l '"effet de cascade" des "séances Pavlo-viennes", abordant leurs impacts sur la psychologie, en particulier sur A.R. Luria et A.N. Léontiev.
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OBJECTIVE: To investigate the value of HE4,CA125 and ovarian malignant tumor risk prediction models(ROMA)in the diagnosis of ovarian epithelial malignant tumors.METHODS: The clinical and pathological data of 247 patients with ovarian tumors(EOC 139 cases,BOT 18 cases,and benign ovarian tumor 90 cases)and 39 patients with uterine fibroids in Liaoning Tumor Hospital from September 2016 to August 2017 were retrospectively analyzed. The levels of serum CA125 and HE4 were measured before operation. The ROMA values were calculated and the relationship between CA125,HE4,ROMA values and clinical pathological parameters were analyzed. The diagnostic evaluation index was calculated,the receiver operating characteristic(ROC)curve was drawn,and the AUC value was also calculated.RESULTS: The positive rate of HE4 in the ovarian epithelial malignant tumor group was significantly higher than that in other groups before and after menopause,the difference being statistically significant(P0.05).There was no significant statistical difference in the positive rate of ROMA before or after menopause(P>0.05).The sensitivity of CA125 was higher than that of HE4 and ROMA. Specificity of HE4 was higher than that of CA125 and ROMA.Correct diagnosis index of ROMA was higher than that of HE4 and CA125.CONCLUSION: For the diagnosis of ovarian malignant epithelial tumors,the combined detection of serum HE4 and CA125 and ROMA model is superior to the individual detection of HE4 and CA125.
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Objective • To investigate the effect of histone H3K14M mutation on the activity of methyltransferase RomA, a secreted effector ofLegionella pneumophila in eukaryotic cells and the underlying mechanisms. Methods • Wide-type histone H3 (H3WT) and mutant histone H3 (the lysine residue 14 was replaced by methionine, isoleucine or arginine residue, and named as H3K14M, H3K14I, and H3K14R, respectively) recombinant expression plasmids were constructed. Packaged lentiviruses with these plasmids were used to infect eukaryotic cells 293T and THP-1 with or without over-expression of RomA. The H3K14 methylation and acetylation were analyzed by Western blotting. The interaction of RomA with H3WT and H3K14 mutants was detected by co-immunoprecipitation. Results • A secreted effector of Legionella pneumophila named RomA targeted the host cell nucleus to upregulate the H3K14 methylation level and downregulate the H3K14 acetylation level for inhibiting the gene expression in host cells and promoting Legionella pneumophila's efficient intracellular replication. But histone H3K14M mutation could promote the interaction between H3K14M and RomA and thus inhibited the methyltransferase activity of RomA. Conclusion • Histone H3K14M mutation significantly inhibits the activity of Legionella pneumophilamethyltransferase RomA.
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Objective To investigate the effects of carcinoembryonic antigen (CEA), carbohy-drate antigen (CA19-9), carbohy-drate antigen (CA125), human epididymis protein 4 (HE4) And the combined detection of ovarian cancer risk prediction model (ROMA) in the diagnosis and significance of endometrial cancer.Methods From May 2014 to May 2010, 80 patients with endometrial cancer were treated.According to its clinical pathology is divided into observation 1 group and observation 2 group.Serum samples were collected and serum CEA, CA19-9, CA125 and HE4 levels were analyzed statistically and the ROMA values were calculated according to menopausal status.Results Compared with the control group, the levels of CEA, CA19-9, CA125 and HE4 in the serum of observation group patients with endometrial carcinoma were significantly higher than those in the control group, the ROMA value of the menopausal state was significantly higher, the difference was statistically significant (P＜0.05).And with the progression of endometrial cancer staging, compared with the observation 1 group, the levels of CA19-9, CA125 and HE4 in the serum of the observation 2 group were significantly higher, the ROMA values of the menopausal states were significantly increased, the difference was statistically significant (P＜0.05).The combined detection rate of CEA, CA19-9, CA125, HE4 and ROMA in serum of patients with endometrial carcinoma was significantly higher than that of each index (P＜0.05).Conclusion The abnormally elevated levels of CEA, CA19-9, CA125, HE4, and ROMA in the serum of patients have important significance and role in the clinical diagnosis of endometrial cancer and its clinical staging.
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Introducción: los trastornos funcionales gastrointestinales son motivo de consulta frecuente en Gastroenterología, y presentan un serio problema social y en la dinámica familiar. El síndrome de intestino irritable en la población pediátrica es poco diagnosticado, y el dolor abdominal crónico es motivo de consulta frecuente en la infancia y adolescencia. Objetivo: analizar los aspectos más actuales en su diagnóstico y tratamiento, y su relación con el dolor abdominal crónico. Métodos: se revisaron las bases documentales de PubMed, Scielo y Latindex y el Registro Especializado del Grupo Cochrane de datos relacionados con el síndrome de intestino irritable hasta diciembre de 2017, así como las guías de tratamiento postuladas por distintas organizaciones médicas, basadas en los criterios de Roma y de la Medicina Basada en la Evidencia. Desarrollo: se realizó una revisión del tema referido a la infancia, y se incluyeron concepto y patogénesis más aceptadas, así como los criterios de Roma establecidos para el diagnóstico. Se hizo énfasis en la etiología, diagnóstico clínico y pruebas diagnósticas. Se analizaron algunos aspectos del tratamiento. Conclusiones: el síndrome de intestino irritable es relativamente frecuente como causa de dolor abdominal crónico funcional, y el interrogatorio dirigido según los criterios de Roma es útil para su diagnóstico. La mayoría de los pacientes con síndrome de intestino irritable en la infancia deben ser atendidos en la atención primaria(AU)
Introduction: gastrointestinal functional disorders are a frequent reason for consultation in Gastroenterology services, and represent a serious social problem and in family dynamics. Irritable bowel syndrome in the pediatric population is poorly diagnosed, and chronic abdominal pain is a frequent reason for consultation in childhood and adolescence. Objective: to analyze the ultimate aspects in its diagnosis and treatment, and its relation with chronic abdominal pain. Methods: PubMed, Scielo and Latindex documentary databases and the Cochrane Specialized Register of data related to irritable bowel syndrome until December 2017 were revised, as well as the treatment guidelines presented by different medical organizations based on the criteria of Rome and of Evidence-Based Medicine. Development: a review of the subject referring to childhood was carried out, and the most accepted concept and pathogenesis were included, as well as Rome criteria established for the diagnosis. Etiology, clinical diagnosis and diagnostic tests were emphasized. Some aspects of the treatment were analyzed. Conclusions: Irritable bowel syndrome is relatively common as a cause of chronic functional abdominal pain, and questioning conducted according to Rome criteria is useful for diagnosis. The majority of patients with irritable bowel syndrome in childhood should be treated in the primary care level(AU)
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Humans , Male , Female , Child, Preschool , Child , Adolescent , Irritable Bowel Syndrome/epidemiology , Abdomen, Acute/complications , Abdomen, Acute/etiology , Adolescent Health/standards , Irritable Bowel Syndrome/complicationsABSTRACT
Resumen En España, muchas actuaciones de erradicación del chabolismo se centraban únicamente en la eliminación de los aspectos más visibles del problema, generando desacuerdo social. Este trabajo analiza en qué medida las nuevas políticas de realojo y dispersión aplicadas recientemente en los poblados chabolistas del noroeste de este país fomentan actitudes favorables hacia la inclusión social de las personas desplazadas, la mayoría de etnia gitana. Para ello se ha realizado un cuestionario que recoge las percepciones tanto de los afectados por los realojos como de las personas que los acogen en sus vecindarios. Mediante el análisis cuantitativo y exploratorio de los datos, se ha detectado una buena predisposición social hacia la inclusión social de las personas chabolistas en las viviendas normalizadas, identificando aquellos aspectos en los que es necesario reforzar este tipo de intervenciones.
Na Espanha, muitas ações de erradicação de favelas foram focadas apenas na eliminação dos aspectos mais visíveis do problema, criando discórdia social. Este artigo analisa em que medida as novas políticas de reassentamento e dispersão recentemente implementadas nas favelas do noroeste do país promovem atitudes favoráveis à inclusão social das pessoas deslocadas, a maioria ciganos. Para isso, foi feito um questionário que captura as percepções de dois grupos: os que foram reassentados e as pessoas que os recebem em seus bairros. Por meio da análise de dados quantitativos e exploratória, temos detectado uma boa predisposição social para a inclusão social dos moradores de favelas em habitações normais, identificando os aspectos que necessitam de reforço dessas intervenções.
Abstract In Spain, many experiences in slum clearance have been focused solely on eliminating the most visible aspects of the problem, creating social dissatisfaction. This article analyzes the extent to which new policies of relocation and dispersion recently applied in the slum areas of northwest Spain, foster favorable attitudes towards social inclusion of the displaced persons, who are mostly Roma. A questionnaire was applied in order to capture the perception of both those affected by relocations and those who receive the displaced persons in their neighborhoods. By quantitative, exploratory data analysis, we have detected a good social predisposition towards social inclusion of underprivileged people in the process of adaptation to live in houses with appropriate infrastructure, identifying those aspects needed to strengthen these kinds of interventions.
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Spain , Rome , Poverty Areas , Policy , DesegregationABSTRACT
Objective To evaluate the significance of HE4 ,CA125 and ROMA indexes in the diagnosis of ovarian cancer in different menopausal status women .Methods After the gynecological mass was taken for pathological diagnosis ,a total of 73 cases of ovarian cancer (ovarian cancer group ,divided into early stage and late stage) and 66 cases of gynecological benign tumor (benign tumor group ) were selected .57 healthy women were selected as controls (control group ) . All groups were further divided into non-menopausal and postmenopausal groups .Serum levels of HE4 and CA125 were measured by chemiluminescence immunoassay and the ROMA index was calculated . Results ① The serum levels of HE4 , CA125 and ROMA in ovarian cancer group were significantly higher than those in benign tumor group and healthy control group (P<0 .01) .② When benign tumor group and control group were taken as a reference , the receiver operating characteristic (ROC ) curve analysis showed that the area under the curve (AUC) of HE4 ,CA125 and ROMA in the non-menopausal group and the postmenopausal group was (0 .944 ,0 .822 ,0 .941 vs .0 .994 ,1 .000 ,1 .000) ,respectively .③ In non-menopausal group ,HE4 has higher specificity and positive predictive value .The best cut off value was 75 .92 pmol/mL ,the diagnostic sensitivity and specificity were 73 .1% and 100% .In postmenopausal group ,CA125 has higher sensitivity , the optimum cut off value was 57 .65 U/mL ,the diagnostic sensitivity and specificity were 100% and 95 .4% .④ In the postmenopausal group ,there was no significant difference in serum CA 125 level between the early and late ovarian cancer patients (P> 0 .05) .Conclusion In the premenopausal group HE4 has a better differential diagnostic value .In postmenopausal group ,the ROMA index could give consideration to both sensitivity and specificity ,and had higher diagnostic efficacy .It plays roles in the diagnosis of ovarian cancer to establish the appropriate reference interval of HE4 ,CA125 and ROMA indexes according to the different menopausal status .